Description

Weight – 0.1kg

It is widely accepted that elevated Low Density Lipoprotein-C (LDL-C) levels are a major risk factor for coronary heart disease which can contribute to endothelial dysfunction and deposition of arteriosclerotic plaque and lesions. Bergamot is the common name of the fruit Citrus bergamia Risso. The fruit differs from other Citrus fruits in the composition and content of its several distinct flavonoids such as neoeriocitrin, neohesperidin, naringin. Citrus Bergamot also contains the novel flavanoid compounds, Melitidine and Brutelidine that have been shown in research to significantly reduce total cholesterol, LDL, Triglycerides, Blood Glucose level; all while increasing High Density Lipoprotein (HDL). The flavonoids in Citrus Bergamot are linked to 3-metil-3–hydroxy glutarile, the substrate of HMG-CoA reductase. Studies of Bergamot suggest that these flavonoid compounds mimic the endogenous substrate for HMG-CoA and interfere with the synthesis of mevalonate, a critical compound at the top of the cholesterol synthesis pathway; in effect acting in similarity to a Statin (a HMG-CoA reductase inhibitor drug). Additionally, Bergamot flavonoids may inhibit the oxidation of LDL as well as reduce oxidative stress whilst polyphenols can also exert beneficial effects on vascular and Cardiovascular Disease (CVD) protection by providing antioxidant, anti-platelet and anti-inflammatory effects. They may also both help improve endothelial function and contribute to stabilization of plaque formed within the arteries. After 6 months of Bergamot supplementation, lipid levels (Total Cholesterol, Triglycerides, and LDL-C) decreased, while the atherogenic lipid pattern improved with increased presence of large and decreased presence of small, dense LDL particles. It has also been suggested that Bergamot increases the fecal excretion of cholesterol, reducing the intestinal absorption and increasing the turnover and excretion of bile acids. The health benefits of Bergamot have been shown to be dramatically improved over phytosterols, policosanol, red yeast rice and other natural products used to lower cholesterol. Coenzyme Q10 (ubiquinone, ubiquinol, CoQ10) is a fat-soluble anti-oxidant vitamin found in most cells and membranes, and is highly-enriched in the inner membrane of mitochondria where it produces energy (ATP) as a component in the electron transport chain through the ability of its benzoquinone head group to accept and donate electrons. Ubiquinone, the oxidized form of CoQ10, is commonly formulated in commercial supplements but it must be reduced to ubiquinol to exert CoQ10’s functions after consumption. The main reason CoQ10 affects lipid profiles is unknown; several mechanisms have been proposed by which CoQ10 supplements could improve lipid profiles. As an intracellular antioxidant, CoQ10 protects the cell membrane phospholipids and mitochondrial membrane protein against free radical-induced damage. It has also been observed that CoQ10 has profound inhibitory effects on in vitro foam-cell formation; white blood cell macrophages which feast on oxidised LDL to generate plaque. CoQ10 has also been implicated to upregulate the Reverse Cholesterol Transport Pathway (RCT pathway) which involves the transport of cholesterol from peripheral tissues to the liver by high-density lipoproteins (HDL), where cholesterol is excreted from the body as bile. The oral bioavailability of ubiquinol recently has been reported to be greater than that of ubiquinone in healthy adults. The data suggested that the enhanced bioavailability of ubiquinol compared to ubiquinone resulted from the reduced coenzyme ubiquinol being more efficiently incorporated into mixed micelles during digestion and its greater uptake. As such, 500mg of patented Bergamonte ® Citrus Bergamot has been included in Love Heart to provide the clinical dose used in studies in a guaranteed patented quality form alongside 200mg of patented Kaneka® Ubiquinol. Aside for dyslipidemia, raised blood pressure (Hypertension) is estimated to cause 7.5 million deaths, about 12.8% of the total of all deaths worldwide. Despite the availability of numerous antihypertensive medications, control of blood pressure to optimal levels remains inadequate in most populations. Hypertension has been termed the silent killer, a symptomless chronic disorder that if left undetected and untreated, silently damages the blood vessels, heart, brain, and kidneys. Grapeseed extract, which contains several polyphenols, especially proanthocyanidins at a dose of 300 mg daily resulted in a significant reduction in blood pressure. A 2011 meta analysis showed grapeseed extract to significantly lower systolic blood pressure and heart rate also. In recent pharmacological studies, Apium graveolens known as celery has demonstrated antioxidant, hypolipidemic and anti-inflammatory activities. The chief compound responsible for the characteristic odor and flavor of celery is 3nB (3-n-butylphthalide). Researchers identified this compound as celery’s active component of celery when seeking to explain the effects of celery in lowering of blood pressure in animal models. In animals, 3nB appears to lower blood pressure by acting as both a diuretic and vasodilator and has also been shown to lower blood cholesterol levels and reduce the formation of arterial plaque in animal preclinical studies. This effect of lowering plaque formation may increase the elasticity of the blood vessels and also lead to lower blood pressure readings. 3nB also appears to promote some effects on systems of the brain, possibly by lowering levels of circulating catecholamines and decreasing vascular resistance and improve vascular flow. With this, 200mg of 10:1 Celery Seed Extract with 400mg Grapeseed extract has been included to aid in lowering hypertension in combination with the Bergamonte® Citrus Bergamot and Kaneka® Ubiquinol to combat dyslipidemia. It’s not only important to look good physically on the outside. We must ensure that we take utmost care of our internal wellbeing. Choose TrainedbyJP Nutrition Love Heart with its patented and clinically dosed ingredients as a part of your daily supplement regime and show your heart the care and love it deserves. Formulated alongside Dr Dean St Mart.   References: Bergamot and Cardio-Metabolic Risk Factors. ClinicalTrials.gov Identifier: NCT02205567 Miceli, N et al. Hypolipidemic Effects of Citrus bergamia Risso et Poiteau Juice in Rats Fed a Hypercholesterolemic Diet. J. Agric. Food Chem., 2007. 55 (26) 10671–10677. Di Donna, L et al. Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides. J Nat Prod. 2009.72(7):1352-4. Kang, P et al. The essential oil of Citrus bergamia Risso induces vasorelaxation of the mouse aorta by activating K(+) channels and inhibiting Ca(2+) influx. J Pharm Pharmacol. 2013. 65(5):745-9. Toth, P P et al. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Front Pharmacol. 2015; 6: 299. Cicero, A et al. Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Arch Med Sci. 2017 Aug; 13(5): 965–1005. Allen, R et al. Coenzyme Q10 Increases Cholesterol Efflux and Inhibits Atherosclerosis through microRNAs. Arterioscler Thromb Vasc Biol. 2014. 34(9): 1795–1797. Jorat, M et al.The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2018; 17: 230. Vitetta L et al. The Plasma Bioavailability of Coenzyme Q10 Absorbed from the Gut and the Oral Mucosa. J Funct Biomater. 2018 Dec 15;9(4). pii: E73. Failla, M L et al. Increased Bioavailability of Ubiquinol Compared to That of Ubiquinone Is Due to More Efficient Micellarization during Digestion and Greater GSH-Dependent Uptake and Basolateral Secretion by Caco-2 Cells. J. Agric. Food Chem. 2014, 62 (29), 7174–7182. Madhav, D et al. A Pilot Study to Evaluate the Antihypertensive Effect of a Celery Extract in Mild to Moderate Hypertensive Patients. Natural Medicine Journal. 2013. 5 (4). Moghadam, M H et al. Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration. J Med Food. 2013 Jun; 16(6): 558–563. Feringa, H et al. The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials. Journal of the Academy of Nutrition And Dietitics 2011.111 (8). 1173–1181. Robinson, M et al. Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension. Journal of Pharmacy and Nutrition Sciences, 2012, 2, 155-159. Disi, S et al. Anti-hypertensive Herbs and their Mechanisms of Action: Part I. Front Pharmacol. 2015; 6: 323. Zhang, H et al. The impact of grape seed extract treatment on blood pressure changes. A meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016. 95(33) 4247.